Penicillin, the first and widely used antibiotic for
treating several bacterial infections was first discovered by Dr Alexander
Fleming. Fleming found out that Pencillium
notatum has the capability to produce the compound for destruction of
surrounding bacterial cells. The discovery led to production of penicillin
antibiotics for wide applications in hospitals. The Penicillin synthesized by
various species of the Penicillium mold
can be of 2 types. One is the naturally occurring penicillin which is formed
during the mold fermentation process and the 2nd type is the
semisynthetic penicillin which is synthesized by altering the structure of
6-aminopenicillanic acid found in all natural penicillin. The structure and characteristics
of the antibiotic are changed to meet the desirable requirements like Oral
medication, drug effectiveness and so on.
The mechanism involved is Penicillium produces the chemical compound penicillin upon facing
danger from different microbes like Staphylococcus bacteria and so on. The
compound inhibits the bacterial growth enzyme and also activates several
enzymes required for cell wall breakdown. As a result, bacterial cells are
killed. As human cells lack cell wall, penicillin is safe to be used. Well
that’s what we assumed at the earlier days.
Now however, with the allergies on the rise against
several antigens, penicillin allergy is one of the most common drug
allergy witnessed by several people worldwide. Penicillin
allergy is the reaction of the host immune system to the antibiotic drug
penicillin. The common symptoms of the allergy
include rash, swelling, hives, itching and so on. Severe reaction includes
anaphylaxis, the life threatening condition which can affect several systems of
the body and cause death. Penicillin and some other compounds with similar
properties can cause the allergic reactions however some events i.e the side
effects faced after intake of penicillin is misunderstood for allergies. Doctor
consultation is a must to differentiate and realize whether the reactions are
just adverse side effects or allergies.
Penicillin Allergy Evaluation must be appropriate as
it can combat infections
and reduce antibiotic resistance. It was observed that 95% of patients with
penicillin allergy indication in medical records were truly not allergic and
showed to have increased infection risk of MRSA (methicillin-resistant Staphylococcus aureus) and Clostridium difficile (C. difficile).
Thus drug allergy must be done appropriately to overcome dangerous infections
and antibiotic resistance which are huge public concerns.
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